–Anatomy suitable patients included. –No FFR in previous trials. •The FAME 2 trial is a multicenter, international, randomized study comparing fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) to best medical therapy (MT) in patients with stable coronary disease. FAME was awarded in response to the NIHR HTA Commissioned Call ref: 18/15 Non-surgical vs surgical management of unstable ankle fractures Dedicated Trial Website For more information on this trial including details on taking part, please visit the dedicated trial website by following the link below! Government has approved Phase-II of FAME Scheme with an outlay of Rs. The FAME 2 trial sought to establish the scientific basis for an FFR-guided PCI strategy for all functionally significant stenoses, but the results make this prospect somewhat unappealing," he wrote. –ISCHEMIA-CKD, CIAO ISCHEMIA. • First cath, then randomization. Prior CABG 5. FAME 2 Trial Clinicaltrials.gov NCT01132495 Bernard De Bruyne, Nico H.J. 10,000 Crore for a period of 3 years commencing from 1st April 2019. The follow-up study, FAME 2 (2012), served to challenge COURAGE by using FFR and demonstrated reduction in urgent revascularization when compared to medical therapy alone. •The study was stopped early because of a significantly higher rate of the composite endpoint of death, MI and urgent Out of total budgetary support, about 86 percent of fund has been allocated for Demand Incentive so as to create demand for xEVs in the country. FAME 3 Trial: FFR-Guided PCI vs. CABG William F. Fearon, M.D. Patients with left main coronary artery disease requiring revascularization 3. Associate Professor of Medicine Director, Interventional Cardiology Stanford University Medical Center • Ancillary studies. Contra-indication to dual antiplatelet therapy 6. Pijls, William F Fearon, Peter Juni, Emanuele Barbato, Pim Tonino, for the FAME 2 study group FAME 2 : FFR-Guided PCI versus Medical Therapy in Stable CAD LVEF < 30% 7. Multicenter, adjudicator-blinded, parallel-group, randomized, controlled trial; N=1,005 FFR-guided PCI (n=509) Angiography-guided PCI (n=496) Previously, the FAME 2 researchers had shown that PCI was initially more expensive than OMT alone, but that the money saved by avoiding repeat revascularization in the year after treatment substantially narrowed that gap. Patients in whom the preferred treatment is CABG 2. FAME-2 TRIAL 1. FAME-2 (Fenofibrate in the Management of Abdominal Aortic Aneurysm 2) was a placebo-controlled randomized trial designed to assess whether administration of 145 mg of fenofibrate/d for 24 weeks favorably modified circulating markers of AAA. • Report of the success in risk factor control • Small sample size (FAME 2) –888 vs. an 8000 pts projection. SCAAR at 10 Years. Design. Dr. Boden was the lead author of the COURAGE trial. Patients with a recent (less than 1 week) STEMI or Non-STEMI 4. The FAME 2 trial began enrolling patients in May 2010 and was designed to evaluate FFR-guided PCI+MT (with second generation drug-eluting stents) versus MT alone in patients with stable CAD. Fearon WF, Nishi T, De Bruyne B, Boothroyd DB, Barbato E, Tonino P, Jüni P, Pijls NHJ, Hlatky MA; FAME 2 Trial Investigators. The analysis of 5-year data from FAME 2, a large trial with long-term follow-up, has “demonstrated clearly that spontaneous MIs are in fact reduced with PCI in patients with stable coronary disease,” Leon stressed.

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